Neurological Emergencies
He S, Pham MH, Zada G, Marquez Y, Giannotta SL
61 Congress of Neurological Surgeons Meeting, Washington DC: October 2011
Key Findings
Take home 1
C5 deficient mice demonstrate decreased white matter ischemia in the corpus callosum
Take home 2
C5 complement protein may play a critical role in mediating white matter injury
Take home 3
C5 may mediate inflammation in the setting of chronic cerebral hypoperfusion.
Take home 4
Astrocyte and microglial activation within the corpus callosum suggests an inflammatory process