Hypoperfusion and Immunoneurological mechanisms

C5 Deficient Mice Demonstrate Decreased White Matter Ischemic Injury after Chronic Cerebral Hypoperfusion.

He S , Liu Q , Scotton TC, Russin J, Mack W.

81st AANS Annual Scientific Meeting, New Orleans: 2013

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Key Findings

Take home 1

C5 deficient mice demonstrate decreased white matter ischemia in the corpus callosum

Take home 2

C5 complement protein may play a critical role in mediating white matter injury

Take home 3

C5 may mediate inflammation in the setting of chronic cerebral hypoperfusion.

Take home 4

Astrocyte and microglial activation within the corpus callosum suggests an inflammatory process

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This work is part of the Neurological Emergencies

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