Hypoperfusion and Immunoneurological mechanisms

Chronic Cerebral Hypoperfusion Induced by Bilateral Carotid Artery Stenosis Induces Selective Recognition Impairment in Adult Mice

Pate A, Moalem A, Cheng H, Babadjouni R, Patel K, Hodis D, Chandegara D, Cen S, He S ,Liu Q.

Neurological Research. Aug 22, 2017.

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Key Findings

Take home 1

C5 deficient mice demonstrate decreased white matter ischemia in the corpus callosum

Take home 2

C5 complement protein may play a critical role in mediating white matter injury

Take home 3

C5 may mediate inflammation in the setting of chronic cerebral hypoperfusion.

Take home 4

Astrocyte and microglial activation within the corpus callosum suggests an inflammatory process

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This work is part of the Neurological Emergencies

section of Significance Labs

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